Varied presentations of congenital ocular synkinesis: do they all fit congenital cranial dysinnervation disorder spectrum? / Apresentações variadas de sincinesias oculares congênitas: todas elas se enquadram ao espectro das desordens congênitas da desnervação craniana?

ABSTRACT Purpose: Synkinesis results from nerve miswirings and causes aberrant movements of the affected muscles. We present a series of cases of rare congenital ocular synkinesis involving the extraocular muscles and the levator palpebrae superioris and speculate the possibility of classifying these entities in the spectrum of congenital cranial dysinnervation disorder. Methods: Records of patients with the diagnosis of congenital ocular synkinesis were analyzed retrospectively. We analyzed the sex, laterality, and complete features of the ocular motility of each patient. Results: Nine patients with congenital ocular synkinesis were included. A slight predominance of women was noted. In terms of laterality, four patients had only the right eye involved, four had only the left eye, and one had both eyes involved. Notably, 55.5% were orthotropic in the primary position. The third, fourth, and sixth cranial nerves were involved in the miswiring in 100%, 44.4%, and 11.1% of the cases, respectively. Conclusions: Congenital synkinesis might present in a very eclectic and uncommon fashion. The aberrant innervation in these cases classifies them into the group of congenital cranial dysinnervation disorders.

RESUMO Objetivo: Sincinesias são resultado de inervações anômalas e ocasionam movimentos aberrantes dos músculos envolvidos. Apresentamos uma série com casos raros de sincinesias oculares congênitas dos músculos extraoculares e do levantador da pálpebra superior e especulamos a possibilidade de classificá-las dentro do espectro das desordens congênitas da desnervação cranianana. Métodos: Prontuários de pacientes com diagnóstico de sincinesia ocular congênita foram estudados retrospectivamente. Analisamos sexo, lateralidade e as características completas do exame de motilidade de cada paciente. Resultados: Nove pacientes com sincinesias oculares congênitas foram incluídos. Houve discreta predominância no sexo feminino. Em termos de lateralidade, o olho direito foi o único envolvido em 4 casos, o olho esquerdo também em 4 casos e 1 caso apresentou acometimento bilateral. 55,5% dos pacientes eram ortotrópicos na posição primária. Os III, VI e IV nervos participaram da sincinesia em 100%, 44,4% e 11,1% dos casos, respectivamente. Conclusões: Sincinesias oculares congênitas podem se apresentar de modo bastante eclético e incomum. A inervação aberrante presente em cada um desses casos os coloca na lista de candidatos a integrar o grupo das desordens congênitas da desenervação craniana.

Síndrome de Marcus-Gunn / Marcus Gunn syndrome

Introducción: El síndrome de Marcus-Gunn se manifiesta con retracción o elevación del párpado ptótico ante la estimulación del músculo pterigoideo del mismo lado y el término "guiño mandibular" es inapropiado ya que el párpado no siempre desciende. Puede producirse en la apertura bucal, masticación, avance mandibular, al sonreír, silbar, bruxar, sacar la lengua, deglutir, chupar, cantar, en la contracción esternocleidomastoidea, maniobra de Valsalva, respirar o inhalar. Es congénito y de modalidad rara y autosómica dominante. Objetivo: Contribuir al conocimiento de esta rara enfermedad y a su relación con el ámbito odontológico. Presentación del caso: Se trata de un niño de 3 años diagnosticado de síndrome de Marcus-Gunn en el periodo neonatal, por la observación de la madre de una apertura palpebral izquierda durante la succión nutritiva. No presenta otras enfermedades ni antecedentes de interés. En la exploración extraoral se advierte una ptosis palpebral derecha y apertura palpebral izquierda en los movimientos mandibulares y deglución. La intensidad del reflejo se incrementa en estados de ansiedad derivados del tratamiento dental. Conclusiones: el síndrome de Marcus-Gunn es una entidad rara en pediatría, en la cual sus hallazgos clínicos determinan el diagnóstico. Teniendo en cuenta que en ocasiones presentan alteraciones oculares, nada nos hace sospechar la presencia de una enfermedad oral específica(AU)

Introduction: Marcus Gunn syndrome manifests with retraction or elevation of the eyelid ptotico while stimulation of the pterygoid muscle on the same side and the term jaw-winking is inappropriate because the eyelid does not always goes down. It can occur during mouth opening, mastication, mandibular advancement, while smiling, whistling, bruxing, sticking out the tongue, swallowing, sucking, singing, during the sternocleidomastoid contraction, the Valsalva maneuver, breathing or inhaling. This syndrome is congenital and rare, and of autosomal dominant modality. Objective: To contribute to the knowledge of this rare disease and its relationship with the odontologic field. Presentation of the case: 3 years old boy diagnosed with Marcus Gunn syndrome in the neonatal period by the observation of the mother of a left palpebral opening during the nutritive sucking. He does not present other diseases or a background of interest. In the extraoral exploration, it is noticed a right palpebral ptosis and a left palpebral opening in the jaw movements and in swallowing. The intensity of the reflex increases in anxiety states arising from the dental treatment. Conclusions: Marcus Gunn syndrome is a rare entity in pediatrics, in which its clinical findings determine the diagnosis. Taking into account that sometimes it presents ocular alterations, nothing makes us suspect the presence of a specific oral disease(AU)

Facial Clinimetric Evaluation Scale and Synkinesis Assessment Questionnaire Translation into Brazilian Portuguese: A Validation Study

Abstract Introduction Facial nerve palsy results in both functional disability and psychological morbidity. There are several well-established grading scales to quantify the quality of life of these patients. Objective Translate and validate the Facial Clinimetric Evaluation (FaCE) scale and Synkinesis Assessment Questionnaire (SAQ) to Brazilian Portuguese. Methods This study adopted a forward-backward translation method and performed cross-cultural adaptation. A pilot study was conducted to correct any confusing language and to evaluate content validity. A validation study was then performed. Internal consistency of the Brazilian Portuguese version of the FaCE and SAQ items was evaluated by Cronbach's alpha coefficient. Construct validity was assessed by Spear- man's Rank Correlation Coefficient between FaCE and SAQ scores to eFACE, House- Brackmann, Short Form 12 (SF-12) and Facial Disability Index (FDI) (sub)scores. Results A total of 90 patients were included. Cronbach's alpha for total domain scored 0.881 for FaCE and 0.809 for SAQ. FaCE total score correlation to eFACE total and House- Brackmann showed Spearman's r value of 0.537 and -0.538, respectively (p < 0.001). SAQ correlation to eFACE synkinesis subdomain was -0.449 (p < 0.001). No correlation was found between SAQ and HB score. FaCE total score correlations were of 0.301 and 0.547 for SF-12 PCS and MCS, respectively (p < 0.001). Correlation between FaCE total and FDI Physical and Social/well-being functions were 0.498 and 0.567 (p < 0.001). Conclusion Brazilian Portuguese FaCE scale and SAQ versions achieved high validity and reliability in the present study. These translated instruments demonstrated good psychometric properties, being proper to use in clinical practice in Brazil and with Brazilian Portuguese speakers.

Trochlear-oculomotor synkinesis: another congenital cranial dysinnervation disorder? / Sincinesia troclear-oculomotora: outro distúrbio congênito de denervação craniana?

ABSTRACT This report documents an unusual phenomenon. A 6-year-old girl with trochlear-oculomotor synkinesis presented with superior oblique and palpebral levator co-contraction. The literature was reviewed and the possibility of classifying this entity as a congenital cranial dysinnervation disorder was speculated.

RESUMO Este relato descreve um fenômeno incomum. Uma menina de 6 anos com sincinesia troclear-oculomotora apresentou co-contração do oblíquo superior e do levantador da pálpebra. A literatura foi revisada e especulou-se a possibilidade de classificar essa desordem como um distúrbio da congenital cranial dysinnervation disorder.

Ten-Year Follow-Up of Transcranial Magnetic Stimulation Study in a Patient With Congenital Mirror Movements: A Case Report

Most studies concerning congenital mirror movements (CMMs) have been focused on the motor organization in the distal hand muscles exclusively. To the best of our knowledge, there is no data on motor organization pattern of lower extremities, and a scarcity of data on the significance of forearm and arm muscles in CMMs. Here, we describe the case of a 19-year-old boy presenting mirror movements. In these terms, a 10-year transcranial magnetic stimulation study demonstrated that the motor organization pattern of the arm muscles was different from that of distal hand and forearm muscles even in the same upper extremity, and that the lower extremities showed the same pathways as healthy children. Moreover, in this case, an ipsilateral motor evoked potentials (MEPs) for distal hand muscles increased in amplitude with age, even though the intensity of mirror movements decreased. In the arm muscles, however, it was concluded that the contralateral MEPs increased in amplitude with age.

Current Treatment Options for Bilateral Vocal Fold Paralysis: A State-of-the-Art Review

Vocal fold paralysis (VFP) refers to neurological causes of reduced or absent movement of one or both vocal folds. Bilateral VFP (BVFP) is characterized by inspiratory dyspnea due to narrowing of the airway at the glottic level with both vocal folds assuming a paramedian position. The primary objective of intervention for BVFP is to relieve patients’ dyspnea. Common clinical options for management include tracheostomy, arytenoidectomy and cordotomy. Other options that have been used with varying success include reinnervation techniques and botulinum toxin (Botox) injections into the vocal fold adductors. More recently, research has focused on neuromodulation, laryngeal pacing, gene therapy, and stem cell therapy. These newer approaches have the potential advantage of avoiding damage to the voicing mechanism of the larynx with an added goal of restoring some physiologic movement of the affected vocal folds. However, clinical data are scarce for these new treatment options (i.e., reinnervation and pacing), so more investigative work is needed. These areas of research are expected to provide dramatic improvements in the treatment of BVFP.

Congenital third nerve palsy with synergistic depression on attempted adduction and trigemino‑oculomotor synkinesis: Underpinnings of a spectral dysinnervation disorder.

The authors describe a case of congenital partial pupil‑sparing third cranial nerve palsy with absent adduction, synergistic depression of globe and widening of palpebral fissure on attempted adduction and synergistic elevation and adduction on mouth opening and sideways thrusting of jaw. The case illustrates trigemino‑oculomotor synkinesis associated with congenital third nerve palsy. The possible mechanism of miswiring involving the medial longitudinal fasciculus and trigeminal nuclei is discussed. At least some cases of congenital third cranial nerve palsy may fall in the realm of congenital cranial dysinnervation disorders (CCDDs) sharing a much wider spectrum of presentation.

The Effective Treatment for Incomplete Recovery after Facial Nerve Paralysis / 대한이비인후과학회지

The facial nerve coursing through the temporal bone provides a challenge to the otologic surgeon. Advances in surgical instrumentation and refinements of surgical strategies enable the otologist to uncover the entire course of the facial nerve safely from brainstem to its exit from temporal bone. The most common cause of facial nerve paralysis is Bell's palsy, followed by traumatic facial paralysis, herpes zoster oticus, and intratemporal tumorous lesion. The surgical approaches to the injured facial nerve depend on its causes. In consideration of selecting surgical technique of facial nerve paralysis reconstruction, clinician must find out thecause, degree and duration of paralysis for the appropriate technique. Although preventing synkinesis is more effective than treating an established one, it has been shown that when patients inevitably has facial sequelae, there is no effective intervention modalities. Numerous facial rehabilitation techniques for such facial problems after facial palsy have been developed to improve cosmesis and function. Recently botulinum toxin A chemical neurectomy has been considered as a best approach in treating facial sequelae. Botulinum toxin injection has shown remarkable results in the disappearance of facial synkinesis within a few days. This procedure helps the patients to recover from lower self-esteem and better quality of life than before.

Sinquinesis óculomotora: dos casos de pacientes excepcionales / Oculomotor synkinesis: two cases excepcional patients

Las sinquinesis son movimientos simultáneos o coordinados en secuencia de mivimientos de músculos suplidos por diferentes nervios o por ramas independientes del mismo nervio que ocurren luego de la recuperación de una lesión axonal periferica; son debidos a la dirección errónea ("misdirection") que toman algunos axones hacia otros músculos que no constituyen su objetivo o blanco; así, cuando el paciente intenta mover algunos músculos, ocurren contracciones involuntarias en otros, no esperadas anatómicamente. Es una suerte de recableado mal realizado y confuso. En las dos pacientes que constituyen nuestro informe, ocurrieron alteraciones óculomotoras excepcionales. En la primera de 60 años portadora de un aneurisma gigante del senocavernoso izquierdo, la sinquinesis nerviosa aberrante ocurrió entre los nervios craneales tercero y sexto. En la segunda de 22 años a quien se resecó un osteocondroma gigante de la fosa media derecha, desarrolló una parálisis total del tercer nerviocraneal con sinquinesis trigémino-oculomotora entre el músculo pterigoideo derecho y el elevador del párpado superior; así como también entre el tercero (recto inferior) y sexto nervios (recto externo) ipsolateral. Se revisa la literatura al respecto.

Synkinesis are simultaneous or coordinated sequential movements of muscles that are supplied by different nerves or have independent nerve branches. They occur after the recovery a peripheral axonal injury. They are due to axons taking a wrong direction ("misdirection") towards muscles that do not constitute their objetives or targets. Thus, when the patient attempts to move a muscle, other muscles show anatomically unexpected involuntary contractions. It is a sort of confusing rewiring. Our report is based on the exceptional oculomotor alterations that occurred in two patients. In the first patient, a 60 years-old female carrying a giant aneurysm of the left cavernous sinus, the aberrant nerve synkinesis ocurred between the third and sixth cranial nerves. In the second patient, a 22 year-old female to whom was resected a giant osteochondroma of the right middle fossa, developed a total paralysis of the third cranial nerve with trigeminal oculomotor synkinesis between the right pterygoid muscle and the elevator of the upper eyelid; as well as between the inferior rectus and ipsilateral external rectus. We review the literature on the subject.

Botulinum Toxin A Treatment for Patients with Periorbital Spasm after Facial Nerve Paresis

PURPOSE: To evaluate clinical features of periorbital spasm and facial asymmetry in the patients who recovered poorly from Bell's palsy and facial trauma and to investigate the effect of Botulinum toxin A as a treatment for periorbital spasm and facial asymmetry. METHODS: Between November 2001 and January 2010, Botulinum toxin injection was performed in 17 patients who had blepharospasm and facial asymmetry following poor recovery from facial palsy. The past history, trauma history, clinical manifestation of blepharospasm, Botulinum toxin A injection dose, injection site, frequency of injection, and duration of effect was evaluated. Data was analyzed using the Mann-Whitney U test, SPSS 12.0. RESULTS: The mean number of injections was 2.7 +/- 2.4 times and the mean dose per injection unit was 12.2 +/- 1.2 units. The Botulinum toxin effect lasted 6.9 +/- 5.5 months in Bell's palsy patients, and 8.0 +/- 4.2 months in trauma patients. There was no significant difference between the 2 groups. Most patients reported improvement of periorbital spasm and facial asymmetry. After treatment, 1 patient complained of epiphora and 1 patient complained of ptosis; conservative treatment was performed for these patients. CONCLUSIONS: Blepharospasm can be treated and a cosmetic improvement in facial symmetry can be achieved by Botulinum toxin A injection in the patients who recover poorly from facial palsy.

Grau de percepção e incômodo quanto à condição facial em indivíduos com paralisia facial periférica na fase de seqüelas / Degree of perception and discomfort regarding facial condition in subjects with peripheral facial paralysis in sequelae stage

OBJETIVO: Correlacionar a auto-avaliação da condição facial do paciente, o grau de incômodo quanto às seqüelas e de prejuízo em atitudes diárias com os dados encontrados na avaliação fonoaudiológica. MÉTODOS: Participaram da pesquisa 29 indivíduos, de ambos os sexos, média de idade de 46 anos, com média de 5,9 sessões de fonoterapia. Realizou-se avaliação fonoaudiológica da simetria e da movimentação da face e verificou-se a presença de sincinesias e contraturas por meio de instrumento publicado e padronizado. Além disso, realizou-se uma entrevista por meio de perguntas fechadas que permitiram a graduação da opinião do paciente quanto à sua própria face e influência desse problema em suas atividades sociais e profissionais. RESULTADOS: Encontrou-se concordância quanto à auto-avaliação do paciente e a avaliação fonoaudiológica (p=0,0029), porém essa correlação não esteve presente em pacientes com menos de três sessões de fonoterapia. Não houve correlação significante entre o grau de sincinesia/contratura e o grau de incômodo referido pelo paciente, assim como o prejuízo em atividades sociais e profissionais não foi associado ao grau de paralisia, sincinesia, ou contratura. No entanto, houve correlação fraca com tendência à significação (r=-0,3250/p=0,085) quando comparou-se a auto-avaliação do paciente com o grau de prejuízo referido. CONCLUSÕES: A autopercepção da condição facial nem sempre é concordante entre o profissional e o paciente, sendo que essa concordância aumenta em pacientes com maior tempo de terapia. Por outro lado, o impacto da condição facial na vida do paciente parece não depender do grau das seqüelas.

PURPOSE: To correlate the self-evaluation of patients with facial paralysis regarding their facial condition, the level of sequelae discomfort and the negative consequences in daily activities, with the results found in clinical assessment. METHODS: Twenty-nine subjects of both genders, with average age of 46 years and an average of 5.9 therapy sessions participated in this study. A clinical evaluation of facial symmetry and movement was carried out, verifying the presence of synkinesis and contractures using a facial grading system proposed by a standardized and published instrument. Moreover, an interview with closed questions was carried out, in order to measure the patient's opinion regarding how his own face influences his professional and social activities. RESULTS: There was an accordance regarding the patient's self evaluation and the clinical assessment (p=0,0029), but this correlation was not found in patients with less than three sessions of the speech therapy. No significant correlation was found between the degree of synkinesis/contracture and the level of discomfort reported by the patient. Furthermore, the negative consequences in professional and social activities were not associated to the degree of facial paralysis, synkinesis or contracture. However, there was a weak correlation tending to significance (r=-0,3250/p=0,085) when the self evaluation was compared to the reported negative consequences. CONCLUSIONS: The patient's self perception of the facial condition is not always in agreement with the professional's assessment, although this agreement increases in patients with longer intervention periods. On the other hand, the impact of the facial condition in the patient's life does not depend on the degree of sequelae.

Electro-acupuncture for Facial Palsy with Synkinesis / 全日本鍼灸学会雑誌

[Objective] For one facial palsy subject with synkinesis, we applied asynchronous 100Hz EAT and examined the effects. We also examined changes in the effects according to various frequencies.<BR>[Methods] We applied EAT to Mm.faciales, and the evaluation was based mainly on EMG findings (the EMG amplitude, EMG survival continuance time) as well as facial palsy score, VAS, ENoG. We examined changes after treatment and observed the process.<BR>[Results] Change in EMG amplitude were not recognized, but the EMG persistance was shortened after treatment and during the process of observation. VAS, facial palsy score, and ENoG were improved. EMG persistance was not changed by 1 Hz EAT, was prolonged by 30Hz EAT, and was shortened by 100 Hz EAT.<BR>[Conclusion] One hundred Hz EAT shortened EMG persistance, and reduced the subjective symptoms of synkinesis. In addition, we were able to improve facial palsy score and ENoG value.

Acupuncture Treatment in a Peripheral Facial Paralysis with the Sequelae / 全日本鍼灸学会雑誌

Bell's palsy, most frequently occurring in peripheral facial paralysis, is a well-recoverable disease showing spontaneous healing in 70% of patients. This chronic patient of Bell's palsy has persisted for more than two years. Many medical institutes have diagnosed that it was very difficult to remedy completely. The rating score was 24 (full score : 40 points), having sequelae of synkinesis, facial spasm, crocodile tears and other problems. By thermography, the temperature difference between the normal side and the paralyzed side was 0.9°C, and the paralyzed side's temperature was lower. To improve microcirculation on the paralyzed side, electro-acupuncture treatment has been applied to the facial nerve and facial expression muscles. <BR>After evaluating mainly the score for facial paralysis and thermography, the score was increased with disappearance of the temperature difference between the normal side and the paralyzed side. Subjectively, it also became easier to move facial expression muscles, and the phenomenon of crocodile tears was decreased. Long-term electro-acupuncture treatment is considered to be effective for improving the microcirculation and enhancing the QOL of the patient.

Botulinum Toxin A for Spasmodic Torticollis, Hemifacial Spasm and Facial Synkinesis

Botulinum toxin type A(BTA) is well known treatment agent in the treatment of paralytic strabismus in ophthalmological field for more than 15 years. Its therapeutic potential as temporary paralyzing agent was adopted to treat several neurologic, movement disorders. In recent years, BTA is considered as initial medical treatment option in such as blepharospasm, hemifacial spasm, spasmodic torticollis, spasmodic dysphonia. Authors applied BTA injection in cases with spasmosmodic torticollis, hemifacial spasm, facial synkinesis and experienced staisfactory result. So authors present our experience of BTA injection therapy and discuss techniques, advantages and disavantages.

Unilateral Blepharoptosis Associated with Paradoxical Movement on Abduction

PURPOSE: This case is the first report of unilateral ptosis associated with paradoxical movement on abduction in Korean literature and we report this case with a successful result of operations. METHODS: We examined an 18-year-old male patient who had showed drooping of right eyelid since birth. The ptosis was exaggerated on abduction. He did not have any remarkable history of illness. Corrected visual acuity was 20/20 in both eyes. Ocular motility examination revealed full range of ductions and versions in all fields of gaze. On exophthalmometric examination, no difference was found in any direction of gaze between two eyes. Under the diagnosis of unilateral ptosis associated with paradoxical movement on abduction, levator resection of right upper lid and blepharoplasty of left upper lid were performed. RESULTS: During operation, we noticed unusual finding that thickened tendon sheath was covering the lateral one third of levator aponeurosis. Paradoxical eyelid movement disappeared completely after secondary operation by removal of the previously noticed tendon sheath as much as possible.

Congenital Levator-Inferior Rectus Synkinesis

We examined a 4-year-old girl who had showed retraction of the left upper eyelid on downward gaze since birth. She had no history of birth trauma, eye surgery, or oculomotor nerve palsy. Corrected visual acuity was 0.3 OU. Motility examination revealed no phoria or tropias. Full ductions and versions were present in all fields of gaze. In primary gaze, the upper eyelids were in normal position and symmetric, and the levator function of the both eyes was normal. On downward gaze, the left upper eyelid was retracted 3.5 mmcompared with the right upper lid. On left and downward gaze, the left upper lid retraction increased to 8 mm. Result of computed tomography of brain and orbits was normal. This case is clinically rare and may be the first report of congenital levator-inferior rectus synkinesis in the Korean literature.

A Case of Unilateral Eyelid Retraction Induced by Depression and Adduction

Various patterns of synkinesis with levator palpebrae have been reported as a phenomenon of the aberrant innervation.Synkinetic levator innervation of extraocular muscles has been reported infrequently.Primary oculomotor synkinesis on attempting to gaze downward and adduction has been once reported to date on a congenital and inherited basis. This report concerns unilateral eyelid retraction induced by depression and adducting eye movement in a 4-year-old girl without any previous oculomotor palsy.

Etiology of Eyelid Retraction in Koreans

Eyelid retraction occurs secondary to various disease entities. To our knowledge, there has not been any report on the etiology of eyelid retraction in Korea. The authors have observed 47 patients with unilateral or bilateral eyelid retraction and studied the etiologies. Eyelid retractions were commonly associated with thyroid ophthalmopathy, traurna and neuropathic causes in adults, and paradoxic synkinesis of levator palpebrae muscle and thyroid ophthalmopathy in children. Unilateral eyelid retractions were most commonly associated with neuropathic causes, and thyroid ophthalmopathy is the most common cause in bilateral eyelid retractions. In contrary to the previous reports, lower lid retraction was characteristically more common than upper lid retraction in thyroid.

A Study on Synkinetic Behavior in Hemifacial Spasm Using Blink Reflex Methodology

BACKGROUND AND PURPOSE: Hemifacial spasm is clinically characterized by involuntary co-contraction of unilateral facial muscles innervated by facial nerve and presence of synkinetic response between facial muscles innervated by different branches of facial nerve is considered as the electrophysiological hallmark of this disease. We performed this study in order to analyse and thereby to approach the pathogenesis of these synkinetic responses in detail. METHODS: Blink reflex test was applied to the 21 patients with hemifacial spasm. With some modification of conventional blink reflex methodology, synkinetic responses between orbicularis oculi and orbicularis oris muscles were recorded on both affected and unaffected sides. RESULTS: Among 21 patients, 10( 47.6% ) showed synkinetic responses both on affected and unaffected side, 8( 38.1% ) only on affected side, and 3( 14.3% ) did not show any evidence of synkinesis on either side. CONCLUSION: These findings could be considered as additional supportive evidence that the facial neuronal hyperexcitability is working in hemifacial spasm as synkinesis on unaffected side cannot be explained solely by peripheral mechanism. Further research on change of synkinetic behavior after microvascular decompression surgery seems to be needed.

Unilateral Retraction the Umlateral Eyelid on Vomiting

I examined a patient who showed retraction of the right eyelid on vomiting. The right eyelid of the patient elevated concomitantly with the induction of gag reflex. She did not have ptosis. The levator function of the both eyes was normal. This case would be the first case report of glossopharyngeal-vagal-oculomoter synkinesis in the literature.